Cryptic crossword clue
Criminal syndicate loses aid, will go into a shell 6

The most common and most likely answer to this crossword clue is the 6 letter word ENCYST

E
N
C
Y
S
T

Buddy explains!

The straight part
We know that "go into a shell" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case go into a shell = encyst.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does ENCYST mean?

ENCYST verb
  1. To enclose within a cyst.
  2. To be enclosed within a cyst.

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