Cryptic crossword clue
Crisis antics are anyhow in vain 12

The most common and most likely answer to this crossword clue is the 12 letter word NARCISSISTIC

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Buddy explains!

The straight part
We know that "vain" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case vain = narcissistic.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does NARCISSISTIC mean?

NARCISSISTIC noun
  1. A narcissist.
NARCISSISTIC adjective
  1. Having an inflated idea of one's own importance.
  2. Obsessed with one's own self image and ego.

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