Cryptic crossword clue
Crosses help us to follow directions initially 4

The most common and most likely answer to this crossword clue is the 4 letter word DSOS

D
S
O
S

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The straight part
We know that "Crosses" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case crosses = dsos.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does DSOS mean?

DSOS noun
  1. A male hybrid of a yak and a domesticated cow.

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