Cryptic crossword clue
Crossword addicts should be used to such setbacks 9

The most common and most likely answer to this crossword clue is the 9 letter word REVERSALS

I've seen this crossword clue in The Daily Telegraph
R
E
V
E
R
S
A
L
S

Buddy explains!

The straight part
We know that "setbacks" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case setbacks = reversals.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does REVERSALS mean?

REVERSALS noun
  1. The state of being reversed.
  2. An instance of reversing.
  3. A change in fortune; a change from being successful to having problems.

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