Cryptic crossword clue
Crossword compiler, about fifty, one taking up residence 7

The most common and most likely answer to this crossword clue is the 7 letter word SETTLER

I've seen this crossword clue in The Times
S
E
T
T
L
E
R


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The straight part
We know that "one taking up residence" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case one taking up residence = settler.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does SETTLER mean?

SETTLER noun
  1. Someone who settles in a new location, especially one who takes up residence in a previously uninhabited place; a colonist.
  2. Someone who decides or settles something, such as a dispute.
  3. That which settles or finishes, such as a blow that decides a contest.
  4. The person in a betting shop who calculates the winnings.
  5. A drink which settles the stomach, especially a bitter drink, often a nightcap.
  6. A vessel, such as a tub, in which something, such as pulverized ore suspended in a liquid, is allowed to settle.

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