Cryptic crossword clue
Cry left mouth of youth with enthusiasm 6

The most common and most likely answer to this crossword clue is the 6 letter word KEENLY

K
E
E
N
L
Y

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The straight part
We know that "with enthusiasm" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case with enthusiasm = keenly.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does KEENLY mean?

KEENLY adverb
  1. In a keen manner.

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