The most common and most likely answer to this crossword clue is the 6 letter word INSANE
I've seen this crossword clue in The Guardian
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More clues leading to the result INSANE
- Mad home — son starts to annoy nearly everyone
- Stupid and senseless to incarcerate son
- Annoying Annie’s not a good idea
- Cuckoo swimming through Paris, say?
- At sixes and sevens, as nine crazy!
- Cuckoo‘s home by French river reportedly
- How person jumping off Pont Neuf might be pronounced?
- Inside restrains a neurotic lunatic
- Deranged, hospitalised, on medicine finally
- It’s mad and stupid, imprisoning saint
Buddy explains!

The straight part
We know that "Cuckoo" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case cuckoo = insane.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.
What does INSANE mean?
INSANE adjective- Exhibiting unsoundness or disorder of mind; not sane; mad
- Used by, or appropriated to, insane persons
- Causing insanity or madness.
- Characterized by insanity or the utmost folly; ridiculous; impractical