Cryptic crossword clue
Cull spurs you to change, taking great care 12

The most common and most likely answer to this crossword clue is the 12 letter word SCRUPULOUSLY

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Buddy explains!

The straight part
We know that "taking great care" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case taking great care = scrupulously.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does SCRUPULOUSLY mean?

SCRUPULOUSLY adverb
  1. In a careful manner, with scruple; done with careful attention to detail.

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