Cryptic crossword clue
Cup tie score upset Brussels fan?  No! 11

The most common and most likely answer to this crossword clue is the 11 letter word EUROSCEPTIC

I've seen this crossword clue in The Times
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Buddy explains!

The straight part
We know that "Brussels fan?  No!" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case brussels fan?  no! = eurosceptic.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does EUROSCEPTIC mean?

EUROSCEPTIC noun
  1. One who is sceptical of European integration, such as the EEC, the EC, the EP, the EU, the Euro, etc.

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