The most common and most likely answer to this crossword clue is the 10 letter word CARETAKERS
I've seen this crossword clue in The Times
C
A
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T
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More clues leading to the result CARETAKERS
Buddy explains!

The straight part
We know that "Custodians" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case custodians = caretakers.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.
What does CARETAKERS mean?
CARETAKERS noun- Someone who takes care of a place or thing; someone looking after a place, or responsible for keeping it in good repair.
- Someone who takes care of a person; a parent, carer or other guardian.