Cryptic crossword clue
Cut off end of toes and padded around, about to replace tip of knuckle 6

The most common and most likely answer to this crossword clue is the 6 letter word DECLAW

D
E
C
L
A
W

Buddy explains!

The straight part
We know that "Cut off end of toes" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case cut off end of toes = declaw.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does DECLAW mean?

DECLAW verb
  1. To surgically remove a cats claws; onychectomy.
  2. To make harmless.

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