Cryptic crossword clue
Cut off old thumb 6

The most common and most likely answer to this crossword clue is the 6 letter word POLLEX

I've seen this crossword clue in The Guardian
P
O
L
L
E
X

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The straight part
We know that "thumb" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case thumb = pollex.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does POLLEX mean?

POLLEX noun
  1. The thumb; the first, or preaxial, digit of the forelimb, corresponding to the hallux in the hind limb. In birds, the pollex is the joint which bears the alula or bastard wing.

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