Cryptic crossword clue
Cut off, some island is in her itinerary 10

The most common and most likely answer to this crossword clue is the 10 letter word DISINHERIT

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The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does DISINHERIT mean?

DISINHERIT verb
  1. To exclude from inheritance; to disown.

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