The most common and most likely answer to this crossword clue is the 6 letter word THRICE
T
H
R
I
C
E
More clues leading to the result THRICE
- Again and again?
- Three times provided by the head of Harrow in an instant
- Most of the cereal, as it can be found in little titbits
- Mo throttled husband several times over
- The short grains seen, again and again
- Article about wealthy shortened again and again
- Three times heretic turns, losing direction
- Cut the grass again and again?
Buddy explains!

The straight part
We know that "again and again?" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case again and again? = thrice.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.
What does THRICE mean?
THRICE adverb- Three times.