Cryptic crossword clue
Cute lips break up, it is subcutaneous inflammation 10

The most common and most likely answer to this crossword clue is the 10 letter word CELLULITIS

I've seen this crossword clue in The Guardian
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Buddy explains!

The straight part
We know that "subcutaneous inflammation" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case subcutaneous inflammation = cellulitis.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does CELLULITIS mean?

CELLULITIS noun
  1. An inflammation of subcutaneous or connective tissue caused by a bacterial infection

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