Cryptic crossword clue
Cutting ties with European throttling missing pupil 10

The most common and most likely answer to this crossword clue is the 10 letter word ESTRANGING

I've seen this crossword clue in Independent
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The straight part
We know that "Cutting ties with" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case cutting ties with = estranging.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does ESTRANGING mean?

ESTRANGING verb
  1. To cause to feel less close or friendly; alienate. To cease contact with (particularly of a family member or spouse, especially in form estranged).
  2. To remove from an accustomed place or set of associations.
ESTRANGING adjective
  1. That estranges; alienating, disorienting.

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