The most common and most likely answer to this crossword clue is the 4 plus 1 plus 6 plus 5 letter word MAKE A FREASH START
M
A
K
E
A
F
R
E
A
S
H
S
T
A
R
T
Buddy explains!

The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.