Cryptic crossword clue
d    One King George invading American state becomes a headache 8

The most common and most likely answer to this crossword clue is the 8 letter word MIGRAINE

I've seen this crossword clue in The Daily Telegraph
M
I
G
R
A
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E


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The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does MIGRAINE mean?

MIGRAINE noun
  1. A severe, disabling headache, usually affecting only one side of the head, and often accompanied by nausea, vomiting, photophobia and visual disturbances.
  2. A neurological condition characterised by such headaches.

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