Cryptic crossword clue
Dangerous reactions involving gold leading to the science of flying machines 11

The most common and most likely answer to this crossword clue is the 11 letter word AERONAUTICS

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Buddy explains!

The straight part
We know that "the science of flying machines" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case the science of flying machines = aeronautics.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does AERONAUTICS mean?

AERONAUTICS noun
  1. The design, construction, mathematics and mechanics of aircraft and other flying objects
  2. The theory and practice of aircraft navigation

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