Cryptic crossword clue
Daughter is instructed about Rex, being very worried 10

The most common and most likely answer to this crossword clue is the 10 letter word DISTRAUGHT

I've seen this crossword clue in The Times
D
I
S
T
R
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Buddy explains!

The straight part
We know that "very worried" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case very worried = distraught.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does DISTRAUGHT mean?

DISTRAUGHT adjective
  1. Deeply hurt, saddened, or worried; distressed.
  2. Mad; insane.

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