Cryptic crossword clue
Debasement of adult taking drug, fixed amount 12

The most common and most likely answer to this crossword clue is the 12 letter word ADULTERATION

I've seen this crossword clue in Financial Times
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Buddy explains!

The straight part
We know that "Debasement" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case debasement = adulteration.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does ADULTERATION mean?

ADULTERATION noun
  1. The action of adulterating, being mixed with extraneous material, illicit substitution of one substance for another.

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