Cryptic crossword clue
Decay rampant and in American buildings 8

The most common and most likely answer to this crossword clue is the 8 letter word ROTUNDAS

I've seen this crossword clue in The Daily Telegraph
R
O
T
U
N
D
A
S

Buddy explains!

The straight part
We know that "buildings" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case buildings = rotundas.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does ROTUNDAS mean?

ROTUNDAS noun
  1. A round building, usually small, often with a dome
  2. (frequently capitalized) A Gothic typeface used in early printed books in Northern Italy, based on a rounded script developed in the 13th cent.; the manuscript hand on which this typeface was based
  3. A roundabout; a road junction at which traffic streams circularly around a central island.

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