The most common and most likely answer to this crossword clue is the 7 plus 8 letter word CLUSTER HEADACHE
C
L
U
S
T
E
R
H
E
A
D
A
C
H
E
Buddy explains!
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.