The most common and most likely answer to this crossword clue is the 8 letter word TIMIDITY
T
I
M
I
D
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T
Y
Buddy explains!
The straight part
We know that "Defect shown by mouse withdrawn from circulation?" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case defect shown by mouse withdrawn from circulation? = timidity.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.
What does TIMIDITY mean?
TIMIDITY noun- Shyness