The most common and most likely answer to this crossword clue is the 10 letter word SPIRITLESS
I've seen this crossword clue in The Times
S
P
I
R
I
T
L
E
S
S
More clues leading to the result SPIRITLESS
- Dejected, post-exorcism?
- Dejected sister, lips quivering
- Languid, having given up the ghost?
- Doing without strong drink –- it’s discouraged
- Dejected, being deprived of whisky?
- Priest is soul losing heart, sadly lacking in ardour
- ‘Medium’ hopefully not so droopy
- Rents going up, it’s not so much weak
- Flat not in need of exorcism?
Buddy explains!

The straight part
We know that "Dejected/post-exorcism?" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case dejected/post-exorcism? = spiritless.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.
What does SPIRITLESS mean?
SPIRITLESS adjective- Lacking energy, drive, motivation or emotion. Enervated.