Cryptic crossword clue
Demerol altered shape again 7

The most common and most likely answer to this crossword clue is the 7 letter word REMODEL

R
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M
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D
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L


Buddy explains!

The straight part
We know that "shape again" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case shape again = remodel.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does REMODEL mean?

REMODEL verb
  1. To change the appearance, layout, or furnishings of.
REMODEL noun
  1. An instance of modification or redecorating.

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