The most common and most likely answer to this crossword clue is the 10 letter word DESPONDENT
I've seen this crossword clue in Independent
D
E
S
P
O
N
D
E
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T
More clues leading to the result DESPONDENT
- Heartsick depression about cut foot
- Wretched name for Slough medical specialty
- Demoralised person in divorce case losing right to support daughter
- Cent losing out to major currency, third going in fall, sad
- Tyrant captures northern retreat – it’s hopeless
- Wretched vagrant depends on handout, ultimately
- Discouraged dipin water feature? The opposite!
- Tyrant captures northern retreat — it’s hopeless
- Hopeless northern haunt in the grip of tyrant
- New study breaking dictator down
Buddy explains!

The straight part
We know that "Demoralised" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case demoralised = despondent.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.
What does DESPONDENT mean?
DESPONDENT adjective- In low spirits from loss of hope or courage.