Cryptic crossword clue
Deny opening to those longing for profitable ventures 7

The most common and most likely answer to this crossword clue is the 7 letter word EARNERS

I've seen this crossword clue in The Times
E
A
R
N
E
R
S


Buddy explains!

The straight part
We know that "profitable ventures" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case profitable ventures = earners.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does EARNERS mean?

EARNERS noun
  1. One who earns money.
  2. A profitable product or scheme.

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