Cryptic crossword clue
Depart quickly from USA flight in bad weather, leaving Florida 8

The most common and most likely answer to this crossword clue is the 8 letter word HIGHTAIL

I've seen this crossword clue in Independent
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Buddy explains!

The straight part
We know that "depart quickly, from USA" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case depart quickly, from usa = hightail.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does HIGHTAIL mean?

HIGHTAIL verb
  1. (usually transitive) To move at full speed, especially in retreat.

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