Cryptic crossword clue
Depart with characters from Middle Avenue 5

The most common and most likely answer to this crossword clue is the 5 letter word LEAVE

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Buddy explains!

The straight part

We know that "Depart" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case depart = leave.

The cryptic/wordplay part

In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does LEAVE mean?

1. To have a consequence or remnant.
2. To depart; to separate from.
3. To transfer something.
4. To remain (behind); to stay.
5. To stop, desist from; to "leave off" (+ noun / gerund).

1. The action of the batsman not attempting to play at the ball.
2. The arrangement of balls in play that remains after a shot is made (which determines whether the next shooter — who may be either the same player, or an opponent — has good options, or only poor ones).

1. Permission to be absent; time away from one's work.
2. Permission.
3. Farewell, departure.

1. To give leave to; allow; permit; let; grant.

1. To produce leaves or foliage.

1. To raise; to levy.

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