Cryptic crossword clue
Dependent on setting one tax cut, unexpectedly large 10

The most common and most likely answer to this crossword clue is the 10 letter word CONTEXTUAL

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Buddy explains!

The straight part
We know that "Dependent on setting" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case dependent on setting = contextual.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does CONTEXTUAL mean?

CONTEXTUAL adjective
  1. Of, pertaining to, or depending on the context of information; relating to the situation or location in which the information was found.

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