The most common and most likely answer to this crossword clue is the 11 letter word WELTSCHMERZ
W
E
L
T
S
C
H
M
E
R
Z
Buddy explains!
The straight part
We know that "Depression" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case depression = weltschmerz.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.
What does WELTSCHMERZ mean?
WELTSCHMERZ noun- (sometimes capitalized) World-weariness; an apathetic or pessimistic view of life; depression concerning or discomfort with the human condition or state of the world.