Cryptic crossword clue
Deputy manager takes a handful of drugs before start of playoff 4

The most common and most likely answer to this crossword clue is the 4 letter word VEEP

V
E
E
P


Buddy explains!

The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does VEEP mean?

VEEP noun
  1. (US politics) The Vice President of the United States; the office of Vice President of the United States, especially during an election cycle where several are in the running for the nomination.
  2. Any vice president (in a corporation, organization, etc.)

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