The most common and most likely answer to this crossword clue is the 6 letter word THIRST
T
H
I
R
S
T
More clues leading to the result THIRST
- Desire a bit of sunshine in most of the days of November
- Craving finally familiar in the present time
- Model put before artist – “that calls for a drink!”
- Top and second to drop three places, needing a drink
- Longing change of T-shirt
- Desire a new T-shirt
- Desire short-sleeved top, when moving south
- Only partially suppressed the first craving
- Craving beer at last in the present time
- Lost shirt? Time and drink will fix that
Buddy explains!

The straight part
We know that "Desire" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case desire = thirst.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.
What does THIRST mean?
THIRST noun- A sensation of dryness in the throat associated with a craving for liquids, produced by deprivation of drink, or by some other cause (such as fear, excitement, etc.) which spots the secretion of the pharyngeal mucous membrane
- The condition producing the sensation of thirst.
- A want and eager desire (for something); a craving or longing.
- Sexual lust
- To be thirsty.
- (usually followed by "for") To desire vehemently.