Cryptic crossword clue
Despatch by returning setter, say, is a stroke of good fortune 7

The most common and most likely answer to this crossword clue is the 7 letter word GODSEND

I've seen this crossword clue in The Daily Telegraph
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Buddy explains!

The straight part
We know that "a stroke of good fortune" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case a stroke of good fortune = godsend.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does GODSEND mean?

GODSEND noun
  1. An unexpected good fortune or benefit; a windfall.

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