Cryptic crossword clue
Desperate one that is going after retreating Dickens character 2-2-3

The most common and most likely answer to this crossword clue is the 9 letter word DO-OR-DIE

D
O
-
O
R
-
D
I
E


Buddy explains!

The straight part
We know that "Desperate one" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case desperate one = do-or-die.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does DO-OR-DIE mean?

DO-OR-DIE adjective
  1. Requiring a determined or desperate effort to avoid the consequences of failure.

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