Cryptic crossword clue
Despise a topsy turvy crowd: that’s natural, so to speak 9

The most common and most likely answer to this crossword clue is the 9 letter word ABOMINATE

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The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does ABOMINATE mean?

ABOMINATE verb
  1. To feel disgust towards; to loathe or detest thoroughly; to hate in the highest degree, as if with religious dread.
  2. To dislike strongly.
ABOMINATE adjective
  1. Abominable; detested.

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