The most common and most likely answer to this crossword clue is the 6 letter word UNMAKE
U
N
M
A
K
E
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The straight part
We know that "Destroy" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case destroy = unmake.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.
What does UNMAKE mean?
UNMAKE verb- To destroy or take apart; to cause (a made article) to lose its nature.