Cryptic crossword clue
Detectives replacing male in regime, doing away with top man 8

The most common and most likely answer to this crossword clue is the 8 letter word REGICIDE

I've seen this crossword clue in The Daily Telegraph
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Buddy explains!

The straight part
We know that "doing away with top man" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case doing away with top man = regicide.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does REGICIDE mean?

REGICIDE noun
  1. The killing of a king.
  2. One who kills a king.

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