Cryptic crossword clue
Determined to get sedated after treatment 4-3

The most common and most likely answer to this crossword clue is the 8 letter word DEAD-SET

I've seen this crossword clue in Financial Times
D
E
A
D
-
S
E
T

Buddy explains!

The straight part
We know that "Determined" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case determined = dead-set.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does DEAD-SET mean?

DEAD-SET noun
  1. The rigid pose a hunting dog assumes when pointing out game to a hunter.
  2. A fixed or stationary condition arising from obstacle or hindrance; a deadlock.
  3. (by extension) A determined effort.
DEAD-SET adjective
  1. Unswervingly dedicated; resolutely determined.
  2. Complete and utter; total.

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