Cryptic crossword clue
Detestable patient is ’ell to deal with 12

The most common and most likely answer to this crossword clue is the 12 letter word PESTILENTIAL

P
E
S
T
I
L
E
N
T
I
A
L

Buddy explains!

The straight part
We know that "Detestable" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case detestable = pestilential.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does PESTILENTIAL mean?

PESTILENTIAL adjective
  1. Of or relating to pestilence or plague.
  2. Having a harmful moral effect (especially one that is believed to spread in the manner of pestilence).
  3. Causing irritation or annoyance.

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