Cryptic crossword clue
Detested duke seen strangling son 8

The most common and most likely answer to this crossword clue is the 8 letter word DESPISED

I've seen this crossword clue in Financial Times
D
E
S
P
I
S
E
D

Buddy explains!

The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does DESPISED mean?

DESPISED verb
  1. To regard with contempt or scorn.
  2. To disregard or ignore.
DESPISED adjective
  1. Hated; viewed with scorn.

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