Cryptic crossword clue
Development of tumours, lo, I spy mutating in chambers 9

The most common and most likely answer to this crossword clue is the 9 letter word POLYPOSIS

P
O
L
Y
P
O
S
I
S

Buddy explains!

The straight part
We know that "Development of tumours" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case development of tumours = polyposis.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does POLYPOSIS mean?

POLYPOSIS noun
  1. A hereditary disease characterised by numerous polyps that erupt in various parts of the body, especially the colon

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