Cryptic crossword clue
Diana’s schedule leads to setbacks

The most common and most likely answer to this crossword clue is the 15 letter word DISAPPOINTMENTS

I've seen this crossword clue in The Guardian
D
I
S
A
P
P
O
I
N
T
M
E
N
T
S

Buddy explains!

The straight part
We know that "setbacks" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case setbacks = disappointments.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does DISAPPOINTMENTS mean?

DISAPPOINTMENTS noun
  1. A feeling of sadness or frustration when a strongly held expectation is not met.
  2. A circumstance in which a strongly held expectation is not met.
  3. That which causes feelings of disappointment.

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