Cryptic crossword clue
Did hound rescue pet mistreated by duke?

The most common and most likely answer to this crossword clue is the 10 letter word PERSECUTED

I've seen this crossword clue in The Times
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Buddy explains!

The straight part
We know that "Did hound" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case did hound = persecuted.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does PERSECUTED mean?

PERSECUTED verb
  1. To pursue in a manner to injure, grieve, or afflict; to beset with cruelty or malignity; to harass; especially, to afflict, harass, punish, or put to death for one's race, sexual identity, adherence to a particular religious creed, or mode of worship.
  2. To harass with importunity; to pursue with persistent solicitations; to annoy.

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