The most common and most likely answer to this crossword clue is the 8 letter word SEPARATE
I've seen this crossword clue in The Guardian
S
E
P
A
R
A
T
E
More clues leading to the result SEPARATE
- Individual copies turned up to evaluate
- Individual copies turned over with speed
- Split peas, ridiculous price
- Divided pears messily consumed
- Part — with ease, if broken?
- Different actor initially in role within grasp
- Repeats a stupid part
- Part when equal bottom — about the last chance
- Notice about a part to be cast on its own
- English sailor monkeys about alone
Buddy explains!

The straight part
We know that "Different" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case different = separate.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.
What does SEPARATE mean?
SEPARATE noun- (usually in the plural) Anything that is sold by itself, especially an article of clothing.
- To divide (a thing) into separate parts.
- To disunite from a group or mass; to disconnect.
- To cause (things or people) to be separate.
- To divide itself into separate pieces or substances.
- To set apart; to select from among others, as for a special use or service.
- Apart from (the rest); not connected to or attached to (anything else).
- (followed by “from”) Not together (with); not united (to).