Cryptic crossword clue
Different strangers Des offended 12

The most common and most likely answer to this crossword clue is the 12 letter word TRANSGRESSED

I've seen this crossword clue in The Times
T
R
A
N
S
G
R
E
S
S
E
D

Buddy explains!

The straight part
We know that "offended" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case offended = transgressed.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does TRANSGRESSED mean?

TRANSGRESSED verb
  1. To exceed or overstep some limit or boundary.
  2. To act in violation of some law.
  3. (construed with against) To commit an offense; to sin.
  4. (of the sea) To spread over land along a shoreline; to inundate.

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