Cryptic crossword clue
Difficulty expressing a concept is a setback in star with no Latin 7

The most common and most likely answer to this crossword clue is the 7 letter word APHASIA

A
P
H
A
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I
A

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The cryptic/wordplay part
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This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
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What does APHASIA mean?

APHASIA noun
  1. A partial or total loss of language skills due to brain damage. Usually, damage to the left perisylvian region, including Broca's area and Wernicke's area, causes aphasia.

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