Cryptic crossword clue
Difficulty going from day one — sugary liquid not good 7

The most common and most likely answer to this crossword clue is the 7 letter word DYSURIA

D
Y
S
U
R
I
A

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The straight part
We know that "Difficulty going" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case difficulty going = dysuria.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does DYSURIA mean?

DYSURIA noun
  1. The experience or condition of experiencing pain while discharging urine, or (rarely) of having difficulty doing so.

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