The most common and most likely answer to this crossword clue is the 8 plus 8 letter word TEETHING TROUBLES
I've seen this crossword clue in The Times
T
E
E
T
H
I
N
G
T
R
O
U
B
L
E
S
Buddy explains!
The straight part
We know that "Difficulty in setting" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case difficulty in setting = teething troubles.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.